Clinical Trials for Colorectal Cancer

What is Colorectal Cancer?

Colorectal Cancer, or Colon Cancer, is the third most common cancer and it begins in the large intestine. It usually starts as small, noncancerous (benign) clumps of cells called polyps that form on the inside of the colon. Over time, some of these polyps can develop into colon cancer and consequently spread to additional areas of the body. Symptoms of colon cancer include a persistent change in your bowel habits, including diarrhea or constipation or a change in the consistency of your stool. Additional symptoms may include bloody stools, abdominal discomfort, fatigue, unexplained weight loss, and a feeling that your bowel doesn’t empty completely.

There are several FDA approved treatments and over the counter medications available to help patients manage the symptoms. While many effective treatments are available, clinical trials may still be your best option as they are working to develop more advanced therapies.

Risk Factors

  • Age
  • Race or Ethnicity
  • Chron’s Disease, Ulcerative Colitis
  • Genetics
  • Diet
  • Lifestyle
  • Diabetes
  • Smoking
  • Alcohol Use


  • A persistent change in your bowel habits, including diarrhea or constipation or a change in the consistency of your stool
  • Rectal bleeding or blood in your stool
  • Persistent abdominal discomfort, such as cramps, gas or pain
  • A feeling that your bowel doesn’t empty completely
  • Weakness or fatigue
  • Unexplained weight loss


  • Surgery
  • Chemotherapy
  • Radiation
  • Targeted Therapy
  • Immunotherapy
  • Supportive (palliative) Care
Colorectal Cancer clinical trials Kansas City

Managing Colon Cancer

Colon cancer can be prevented with early detection which is done simply by a procedure called a coloscopy. American Cancer Society Guidelines recommend all patients begin to get colonoscopies starting at age 45 or earlier if you have a family history of cancer or colon cancer. (Colorectal Cancer screening Guidelines)

During colonoscopies, specialists look for abnormalities within the colon such as polyps, growths inside the colon. These polyps can be removed up to a specific size if caught early. This is considered early disease and can be managed with little to no treatment. When a colon polyp grows too large, you may need to undergo surgery to remove it. Polys left unaddressed could lead to colon cancer. Cancer that is localized to the colon is easier to diagnose and treat. If at any time the cancer spreads to other organs, it is considered metastatic cancer.

Your healthcare provider will be able to inform you of the treatment options available to you that will give you the best chance in making an informed decision on your treatment path. Treatment options may include surgery to remove the tumor, radiation, immunotherapy, chemotherapy, and supportive (palliative) care. Clinical trials may also be an option for you as they provide opportunities for alternative treatments.

Be sure to discuss all of your options with your healthcare provider.

colorectal cancer treatments Kansas City
Currently Enrolling

Trials at KCRI

No Current trials – Check back soon

Colorectal Cancer

Learn More

FAQs about Colon Cancer

Frequently Asked Questions

Can KCRI diagnose colon cancer?

Yes. KCRI can perform the colonoscopy necessary to identify polyps in the colon. Once diagnosed, we may refer you to a specific oncologist based on your unique circumstances and specific advancement.

Can colon cancer be removed?

If caught early enough, yes, these cancerous cells can be intercepted. However, if it is embedded into the wall of the colon or advanced to other areas of the body such as the lymph nodes, this means it has reached a greater stage and must be referred to an oncologist.

Are there any treatments for colon cancer?

There are first-line, second-line, and third-line treatments for colon cancer. This means you have to have failed a certain type or types of treatments before you can try others.

For example, specific medications can be used to treat colon cancer, but they are only proven effective for certain patients. Your oncologist may perform genetic typing to understand whether you may be a candidate for a more targeted therapy.


Does KCRI offer colon cancer trials?

It is common for KCRI to offer a clinical trial to treat colon cancer as long as that trial does not require an in-house stay. View our current trial options Here!

Colorectal Cancer Facts:


The Colorectal Cancer Facts & Figures report provides a comprehensive overview of colorectal cancer in the US, including statistics on colorectal cancer occurrence, as well as information about risk factors, prevention, early detection, and treatment.


2020-2022 Report

Don't see the study you're looking for?

Those that Participate:

  • See a board-certified physician at no cost
  • Have access to possible new treatment options before the general public
  • May be compensated for time and travel

We are continually getting new research studies for all types of conditions. Submit your information today to be contacted for upcoming research opportunities.

Contact Us